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writhe - To make continual twisting, squirming movements or contortions of the body

The soccer player writhed in pain on the ground after spraining his ankle.

noun

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throes - Intense or violent pain and struggle, especially accompanying birth, death, or great change

Samantha experienced agonizing pain during the throes of childbirth.

noun

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inflammation - A physical condition characterized by redness, heat, swelling, and pain, often as a response to injury or infection.

The redness of the big toe was caused by an infection, and the inflammation was visible and painful.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

noun

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hardship - Severe suffering or difficulty caused by lack of necessities like food, money, or shelter.

Many families are facing economic hardship due to rising living costs.

noun

See verb

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burden - something you carry or withstand with much difficulty.

Financial debt can be a huge burden on families.

noun

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affliction - Something that causes pain or suffering.

When Pharoah didn't let the people go, Moses gave Egypt one affliction after another.

noun

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agony - Extreme physical or mental suffering

Max was in physical agony as he rode his bicycle up the long mountain trail, but spiritually and emotionally he was in heaven.

adjective

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traumatic - Causing severe and lasting emotional shock and pain.

Bill survived the hurricane at sea on his fishing boat, but it took years for him to recover emotionally from the traumatic experience.

noun

See verb

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torment - Severe physical or mental suffering

Sufferers of depression must deal with the torment of their own thoughts on a regular basis.

adjective

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tragic - Something very sad often involving suffering.

The story of how Oedipus mistakenly killed his father and married his mother is a tragic story.

adjective

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impoverished - Very poor.

We can hardly imagine how impoverished the average person was during the Middle Ages.