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delirious - In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.

After three sleepless nights, he was delirious and barely able to speak clearly.

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kooky - Strange and different, in a funny way

Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.

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daffy - Silly, different, strange, and funny

Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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crackpot - A slightly strange or foolish person

Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.