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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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delirious - In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.

After three sleepless nights, he was delirious and barely able to speak clearly.

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catatonic - Appearing to be in a daze or stupor; unresponsive, not moving or reacting.

His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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weirdo - A person whose dress or behavior seems strange

The weirdo kept peeking at everyone from behind the bushes.

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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.

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batty - Mad and slightly crazy, usually in a humorous way

The computer system wouldn't let Greg log on or change his password, and it was driving him batty.

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kooky - Strange and different, in a funny way

Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.

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psycho - A person with severe mental health issues, often describing someone who behaves in an erratic or dangerous manner.

She accused him of being a psycho and told him to leave after he repeatedly showed up uninvited and acted innappropriately.