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significant - Having a major impact or effect; something that carries weight or importance.

The discovery of the ancient ruins was a significant breakthrough in the field of archaeology.

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supreme - (of authority or an office, or someone holding it) superior to all others

In Iran, the Ayatollah is the supreme ruler who controls the country's population.

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ramifications - The possible results of an action

Being Aristotle's student, Alexander the Great was able to plan out a military strategy taking into account all its ramifications.

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stature - The quality or state of being important or admired based on achievements or reputation

The stature of the company has increased significantly since it went public

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bigwig - A VIP (very important person) or influential decision-maker, often used informally.

Only the bigwigs got access to the exclusive boardroom on the top floor of the company's headquarters.

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transcendent - Extremely great, and ​going beyond the usual limits

John and Esther loved going to Beethoven concerts, because they were always rewarded with a transcendent experience.

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status - A person’s or thing’s level of importance or prestige.

He gained status in the company after his promotion.

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momentous - Important because of the effect it has on the future

Neil Armstrong's first step on the moon was a momentous event because it gave people the feeling that nothing was beyond their reach.

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crucial - Of central and extreme importance

As they left for the plane, the parents knew it was crucial that all the members of the family had their passports.

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indispensable - Impossible to replace or substitute due to its significance.

Water is indispensable for human survival.

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phenomenal - Very remarkable; extraordinary

Mark Zuckerberg started Facebook in his Harvard dorm room, and turned it into one of the largest companies in the world, and everyone would agree that that Facebook has been a phenomenal success.

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caliber - The quality or standard of someone's ability or character.

The company is looking to hire engineers of top caliber.