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fatigue - Extreme tiredness, typically resulting from mental or physical exertion or illness

After working for 15 hours straight, a strong cup of coffee did nothing to help Jolene's fatigue.

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pooped - Extremely tired

After working all night, Sara was too pooped to even go home to her own bed.

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Breakdown - A mechanical failure, especially of a vehicle or machine. Can also be used in medical contexts.

She had an emotional breakdown after losing her job and going through a divorce.

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sputter - Make a series of soft explosive sounds, typically when being heated or as a symptom of a fault

The SUV's engine sputtered as it struggled to haul the trailer behind it.

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wither - (of a plant) become dry and shriveled

The plant withered and died after Mona forgot to water and feed it.

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decrepit - (of a person) elderly and infirm

Maryanne was viewed as decrepit due to her age-related physical ailments, but she was as feisty and sharp as people half her age.

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frail - (of a person) weak and delicate

The strongest marriages last even when one spouse is in frail health.

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foible - A minor fault or weakness in someone's character.

Before going to sleep, Alan prayed "I am sorry about the terrible thing I did today, but please forgive me because You know that all people make mistakes and have foibles."

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lax - Not sufficiently strict, severe, or careful

Due to lax safety standards, the train derailed and injured dozens of passengers.

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plead - Make an emotional appeal

The starving orphan pleaded with the cook to give him more porridge.

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Derail - To obstruct or divert from an expected or intended course.

The train was derailed by a fallen tree during the storm.

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Beg - To plead or request strongly due to need or emotion.

When he lost his job, he was so hungry that he had to beg strangers for something to eat.