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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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Compulsion - A strong, irresistible urge to do something, often against one's better judgement.

His gambling problem stemmed from a deep psychological compulsion.

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Delirious - In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.

After three sleepless nights, he was delirious and barely able to speak clearly.

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delusional - Seeing or believing things that are not real

Betty was confident that she would be a millionaire by the time she would be 25, but her friends thought she was delusional.

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zany - Amusingly unconventional and different

Einstein was unique among geniuses in that he also had a silly and zany side of his personality.

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kooky - Strange and different, in a funny way

Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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Loudmouth - Someone who speaks loudly and without thinking, often causing trouble or embarrassment.

He was a real loudmouth, always bragging about his achievements and never listening to others.

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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Blabbermouth - An overly talkative person who speaks without thinking.

Don't tell Jerry things you don't want others to know about, because you can’t trust a blabbermouth with secrets.